SCI Publications

2008


C.R. Butson, C.C. McIntyre. “Current Steering to Control the Volume of Tissue Activated During Deep Brain Stimulation,” In Brain Stimulation, Vol. 1, No. 1, pp. 7--15. January, 2008.
DOI: 10.1016/j.brs.2007.08.004
PubMed ID: 19142235

ABSTRACT

×
BACKGROUND: Over the last two decades, deep brain stimulation (DBS) has become a recognized and effective clinical therapy for numerous neurological conditions. Since its inception, clinical DBS technology has progressed at a relatively slow rate; however, advances in neural engineering research have the potential to improve DBS systems. One such advance is the concept of current steering, or the use of multiple stimulation sources to direct current flow through targeted regions of brain tissue.

OBJECTIVE: The goals of this study were to develop a theoretical understanding of the effects of current steering in the context of DBS, and use that information to evaluate the potential utility of current steering during stimulation of the subthalamic nucleus.

METHODS: We used finite element electric field models, coupled to multi-compartment cable axon models, to predict the volume of tissue activated (VTA) by DBS as a function of the stimulation parameter settings.

RESULTS: Balancing current flow through adjacent cathodes increased the VTA magnitude, relative to monopolar stimulation, and current steering enabled us to sculpt the shape of the VTA to fit a given anatomical target.

CONCLUSIONS: These results provide motivation for the integration of current steering technology into clinical DBS systems, thereby expanding opportunities to customize DBS to individual patients, and potentially enhancing therapeutic efficacy.


S.P. Callahan, J.H. Callahan, C.E. Scheidegger, C.T. Silva. “Direct Volume Rendering: A 3D Plotting Technique for Scientific Data,” In Computing in Science and Engineering, Vol. 10, No. 1, pp. 88--92. 2008.


S.P. Callahan. “Adaptive Visualization of Dynamic Unstructured Meshes,” SCI Technical Report, No. UUSCI-2008-003, Note: Ph.D. Thesis, University of Utah School of Computing, 2008.


S.P. Callahan, C.T. Silva. “Image-Space Acceleration for Direct Volume Rendering of Unstructured Grids using Joint Bilateral Upsampling,” SCI Technical Report, No. UUSCI-2008-002, University of Utah, 2008.


S.P. Callahan, J. Freire, C.E. Scheidegger, C.T. Silva, and H.T. Vo. “Towards a Provenance-Enabling ParaView,” In Proceedings of the Second International Provenance and Annotation Workshop (IPAW 2008), pp. 120--127. 2008.


J. Cates, P.T. Fletcher, Z. Warnock, R.T. Whitaker. “A Shape Analysis Framework for Small Animal Phenotyping with Application to Mice with a Targeted Disruption of Hoxd11,” In Proceedings of the 5th IEEE International Symposium on Biomedical Imaging (ISBI '08), pp. 512--516. 2008.
DOI: 10.1109/ISBI.2008.4541045


J. Cates, P.T. Fletcher, M. Styner, H. Hazlett, R.T. Whitaker. “Particle-Based Shape Analysis of Multi-Object Complexes,” In Proceedings of the 11th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI '08), Lecture Notes In Computer Science (LCNS), pp. 477--485. 2008.
ISBN: 978-3-540-85987-1


A.N.M. Imroz Choudhury, K. Potter, S.G. Parker. “Interactive Visualization for Memory Reference Traces,” In Computer Graphics Forum, In Proceedings of EuroVis 2008, Vol. 27, No. 3, pp. 815--822. May, 2008.


J.D. Daniels, T. Ochotta, L. Ha, C.T. Silva. “Spline-Based Feature Curves from Point-Sampled Geometry,” In The Visual Computer, Vol. 24, No. 6, pp. 449--462. 2008.


J.D. Daniels, C.T. Silva, J. Shepherd, E. Cohen. “Quadrilateral Mesh Simplification,” In ACM Transactions on Graphics - Proceedings of ACM SIGGRAPH Asia 2008, Vol. 27, No. 5, 2008.
DOI: 10.1145/1409060.1409101


S.B. Davidson, J. Freire. “Provenance and Scientific Workflows: Challenges and Opportunities,” In Proceedings of the 2008 ACM SIGMOD International Conference on Management of Data, pp. 1345--1350. 2008.
ISBN: 978-1-60558-102-6


C. Dietrich, J. Comba, L. Nedel, C.E. Scheidegger, C.T. Silva. “Edge Groups: A New Approach to Understanding the Mesh Quality of Marching Methods,” In IEEE Transactions on Visualization and Computer Graphics (Proceedings of IEEE Visualization 2008), Vol. 14, No. 6, pp. 1651 - 1666. 2008.
DOI: 10.1109/TVCG.2008.122


G. Draper, R. Riesenfeld. “Who Votes For What? A Visual Query Language for Opinion Data,” In IEEE Transactions on Visualization and Computer Graphics, Vol. 14, No. 6, IEEE, pp. 1197--1204. Nov, 2008.
DOI: 10.1109/tvcg.2008.187


G. Draper, Y. Livnat, R. Riesenfeld. “A Visual Query Language for Correlation Discovery and Management,” In Proceedings of Visual and Iconic Language Conference (VaIL 2008), pp. 14--23. 2008.


T. Ellkvist, D. Koop, E.W. Anderson, J. Freire, C.T. Silva. “Using Provenance to Support Real-Time Collaborative Design of Workflows,” In Proceedings of the Second International Provenance and Annotation Workshop (IPAW 2008), pp. 266--279. 2008.


T. Ellkvist, D. Koop, J. Freire, C.T. Silva, L. Stromback. “Using Mediation to Achieve Provenance Interoperability,” In Proceedings of the 2008 Fourth IEEE International Conference on eScience, pp. 398--399. 2008.


A. Fedorov, E. Billet, M.W. Prastawa, G. Gerig, A. Radmanesh, S.K. Warfield, R. Kikinis, N. Chrisochoides. “Evaluation of Brain MRI Alignment with the Robust Hausdorff Distance Measures,” In Lecture Notes in Computer Science, Vol. 5358, Springer, pp. 594--603. 2008.
DOI: 10.1007/978-3-540-89639-5_57


P.T. Fletcher, S. Venkatasubramanian, S. Joshi. “Robust Statistics on Riemannian Manifolds via the Geometric Median,” In IEEE Conference on Computer Vision and Pattern Recognition (CVPR 2008), pp. 1--8. 2008.
DOI: 10.1109/CVPR.2008.4587747


N.L. Foster, A.Y. Wang, T. Tasdizen, P.T. Fletcher, J.M. Hoffman, R.A. Koeppe. “Realizing the Potential of Positron Emission Tomography with 18F-Fluorodeoxyglucose to Improve the Treatment of Alzheimer,” In Journal of the Alzheimer, Vol. 4, No. 1, Suppl. 1, pp. S29--36. 2008.
PubMed ID: 18631997


N. L. Foster, A.Y. Wang, T. Tasdizen, K. Chen, W. Jagust, R.A. Koeppe, E. Reiman, M.W. Weiner, S. Minoshima. “Cerebral Hypometabolism Suggesting Frototemporal Dementia in an Alzheimer’s Disease Clinical Trial,” In Neurology, Vol. 70, No. 11, pp. A103. 2008.